The GiveWell Blog

Podcast Episode 27: Scrutinizing One of Our Longest-Funded Programs

April 2, 2026 | by GiveWell Staff

Vitamin A supplementation is one of the programs GiveWell has supported the longest, and we’re currently funding it in many African countries. The program has an unusually strong evidence base for reducing child mortality, with multiple randomized controlled trials. Yet, as is the case for most global health programs, the evidence for vitamin A supplementation has complex, unresolved questions, such as how well findings from decades-old trials apply today and the extent to which existing research has been influenced by publication bias. As GiveWell’s research team has grown over the last several years, we have expanded our capacity to carefully research these questions.

In this episode, GiveWell CEO and co-founder Elie Hassenfeld speaks with Senior Researcher Stephan Guyenet about the evidence base for vitamin A supplementation, the complications in applying that evidence to our funding decisions, and how GiveWell has improved our cost-effectiveness estimates for the program.

Podcast Episode 26: Investing in Information for Greater Future Impact

March 19, 2026 | by GiveWell Staff

GiveWell’s primary focus has always been researching, identifying, and directing donations to programs we believe will do the most good. When GiveWell first started, we approached this by looking for organizations that were already delivering highly cost-effective, evidence-backed programs and directing funding to those programs. Over time, we were able to focus further upstream by first identifying highly cost-effective programs and then supporting the development of organizations to deliver them.

We’ve been able to take an even more expansive view as our research team doubled in size over the last several years. In addition to our core grantmaking, we’re now funding an increased number of grants designed to provide information that we think will help us direct more funding to highly cost-effective programs in the future. This includes things like generating research about program effectiveness, scoping new promising programs, and piloting program variations.

GiveWell has long made some grants aimed at improving our knowledge base, but this work has now grown substantially and become more systematic. In 2025, GiveWell made 18 grants, totaling approximately $39 million, that were aimed specifically at getting more information to improve future funding decisions. In our latest podcast episode, GiveWell CEO and co-founder Elie Hassenfeld speaks with Program Director Julie Faller about these “value of information” grants.

Podcast Episode 25: Following the Data on Dispensers for Safe Water

March 5, 2026 (updated on: March 17, 2026) | by GiveWell Staff

GiveWell aims to find and fund programs that will do the most good per dollar. To do this, we carefully evaluate potential grants before making them—assessing academic evidence, building cost-effectiveness models, and talking to people in the sector who know the program well.

But our work doesn’t stop there. When a program we’ve supported nears the end of their funding, we also regularly evaluate its results to decide whether to continue our support. This typically involves gathering and analyzing extensive monitoring data. In most cases, the results are consistent with what we expected, and we renew the programs’ support. But sometimes we decide that, even if a program is doing a lot of good, it may not be having the impact we expected. In that case, we decide not to renew our support and instead direct those funds to where we think they’ll do much more good for people in need.

In this episode, GiveWell CEO and co-founder Elie Hassenfeld speaks with Senior Program Officer Erin Crossett about the research that led GiveWell not to renew support for Evidence Action’s Dispensers for Safe Water—a program that installs chlorine dispensers at rural water points so that households can treat their drinking water and reduce waterborne disease—in Malawi and Uganda.

Podcast Episode 24: Testing New Strategies to Increase Vaccination Coverage

February 19, 2026 (updated on: February 24, 2026) | by GiveWell Staff

Vaccines are remarkably effective at preventing deadly diseases, and, while global needs for them are great, vaccines already receive substantial global funding. This creates a challenge: How do you identify opportunities where additional funding can meaningfully increase vaccination rates and save lives?

GiveWell has long recognized the potential for highly cost-effective vaccine programs. We started supporting vaccination programs in 2015 and have made over $200 million in vaccination-related grants to date. For example, New Incentives, one of our Top Charities, aims to increase routine childhood vaccinations in northern Nigeria by providing small cash incentives to caregivers who bring their children into clinics for vaccinations.

Over the past several years, we’ve been growing our research team and laying the groundwork to expand the scope of our work and funding.

In this episode, GiveWell CEO and co-founder Elie Hassenfeld speaks with Natalie Crispin, who leads GiveWell’s vaccination grantmaking. They discuss how our research approach has evolved and what it means for helping more children access life-saving vaccinations.

Podcast Episode 23: Generating Evidence for the Future of Malaria Prevention

February 5, 2026 (updated on: February 6, 2026) | by GiveWell Staff

Seasonal malaria chemoprevention (SMC)—a program that provides preventive antimalarial medication to young children during the months when malaria is mostly likely to be transmitted—is one of the most cost-effective programs GiveWell has identified. Malaria Consortium’s SMC program has been one of our Top Charities since 2016, and we’ve recommended more than $500 million in grants to the program.

Most of our funding to date has supported programs in West Africa, where strong evidence gives us confidence in the effectiveness of the drug combination used. In eastern and southern Africa, malaria chemoprevention programs could potentially help many more children, but we have substantial uncertainties about drug effectiveness in that region.

In this episode, GiveWell CEO and co-founder Elie Hassenfeld speaks with Senior Researcher John Macke about the CHAMP trial, a randomized controlled trial of chemoprevention drugs we’re supporting in Malawi, and how it could shape our malaria grantmaking.

This research is one example of how GiveWell is building for the future: investing in research now that could substantially expand our ability to direct funding cost-effectively in the years ahead.

Podcast Episode 22: Evolving Our Research Approach for Greater Impact

January 22, 2026 | by GiveWell Staff

GiveWell is often thought of for its Top Charities, but over the last several years, we’ve been substantially broadening our work. We’ve developed new ways to identify potential grantees, funded research to fill gaps in our understanding, and explored new program areas where we believe cost-effective opportunities exist but other funders aren’t investing. This increased breadth isn’t a goal in itself—we’ve been laying the groundwork to deliver more impact, now and in the future.

In this episode, GiveWell CEO and co-founder Elie Hassenfeld speaks with Senior Program Officer Julie Faller about how our research approach has evolved and what it means for the future of our grantmaking.

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